Hamilton Secondary College is located in the inner southern suburbs just 15 minutes from the Adelaide city centre and is well serviced by public transport. Close by is Flinders University, Tonsley Innovation precinct, Marion Shopping Centre, Gymnastics SA Training Centre, an Olympic-standard aquatic centre and the beach.
The College is set on extensive grounds surrounded by historic gum trees. Hamilton Secondary College is a designated Science, Technology, Engineering and Mathematics (STEM) school and has innovative programs in this area, including the Mission To Mars project and the STEM Innovation Academy. This offers a unique specialist STEM pathway for students from Year 8 to Year 12.